While nuclear DAAO activation kick-started DNA damage repair proteins and caused DNA strand breaks, mitochondrial-bound DAAO did not cause either of these effects. Additionally, DAAO-produced hydrogen ...

Released mitochondrial DNA (mtDNA) was detected in the cytosol ... serum alanine aminotransferase levels, indicating liver damage. Motor neuron analysis showed reduced neuron counts in the ...

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant ...

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant ...

DNA is susceptible to damage caused by errors committed during replication ... Ligase IIIa is expressed ubiquitously and is implicated in DNA repair and is essential for mitochondrial function. Ligase ...

The other two chapters in this section cover responses to abnormal DNA replication and DNA damage during S phase ... caused by mutations generated during mitochondrial DNA replication, and ...

From rethinking mitochondrial lingo and dogma to exploring the mechanisms ... tackled the assumption that hydrogen peroxide produced by mitochondria caused DNA damage. Armed with inducible peroxide ...

A study reveals cannabis and tobacco use harm sperm quality and DNA integrity, with cannabis causing greater damage, raising ...

This compromises the body's ability to repair oxidative DNA damage, the by-product of normal cellular processes, heightening the risk of certain cancer in these workers, explain the researchers.

Melatonin supplementation may help offset the DNA damage associated with night shift work by boosting the body's ability to repair it, suggest the findings of a small clinical trial published ...

In mice with Leigh Syndrome—the most common childhood mitochondrial disease—the HypoxyStat drug extended lifespan by more than three-fold and reversed brain damage and muscle weakness ...

During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via ...