In a step toward treating mitochondrial diseases, researchers at the University Medical Center Utrecht and their colleagues have used mitochondrial base editing (mtBE) to successfully edit harmful ...
Scientists have found DNA in the nucleus of brain cells, where it shouldn’t be. Bits of genes that typically reside in mitochondria insert themselves at unexpectedly high rates into brain cells’ ...
Patch-clamp recordings demonstrated that LHON neurons, which typically exhibit impaired sodium and potassium currents, showed restored electrophysiological function after co-culture with MSCs.
The AHA recommended whole exome or whole genome sequencing as first-line diagnostic tools for mitochondrial diseases.
Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges. Despite advancements in ...
Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial DNA (mtDNA). This condition can cause symptoms including muscle weakness, ...
Mitochondria are semi-autonomous organelles containing their own DNA (mtDNA), which exhibits a higher mutation rate compared to nuclear DNA. Accumulation of mtDNA mutations is associated with aging ...
Stanford University-led researchers report that tumor cells hijack mitochondria from immune cells, reducing anti-tumor immune ...
For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these mutations cause serious diseases that pass down only through mothers. They ...
Millions of people worldwide live with mitochondrial diseases. These are inherited conditions that make it hard for the body’s cells to produce energy. For a long time, patients had few options ...
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