The opioid-modulating peptides NPFF and RFRP-3 selectively activate NPFFR1 and NPFFR2 through a message–address binding mechanism, where conserved motifs at the peptides’ C-termini engage the ...

“The secret of life is molecular recognition—the ability of one molecule to ‘recognize’ another through weak bonding interactions,” said Linus Pauling, a two-time Nobel Prize winner. In biological ...