Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Making sure that your workout is working for you can be one of the most important parts of planning out your fitness journey, but what is muscle activation and how can you go about achieving it?

Skeletal muscle mechanics and force generation are governed by complex interactions between contractile proteins and passive structural elements. At the cellular level, the sarcomere – the fundamental ...