Researchers at the University of Oklahoma have developed a breakthrough method of adding a single nitrogen atom to molecules, unlocking new possibilities in drug research and development. Now ...

One small atom can make a big difference in a molecule’s pharmacological properties. Especially if that atom is a nitrogen. Chemists at the University of Oklahoma have now unveiled a new strategy for ...

Heterocycles, molecular rings found in many pharmaceuticals, have a reputation for stubbornly resisting modification. That is, in a heterocycle, heteroatoms of one type aren’t easily swapped for ...

As a graduate student at the University of California, Berkeley, Mark Levin started sketching out ideas for how to do something no chemist had ever managed before: swapping one of the carbon atoms in ...

Skeletal editing is a modern approach to chemical synthesis. By making precise alterations at the atomic level, researchers are able to directly convert existing drug scaffolds into new, biologically ...