Researchers at the University of Oklahoma have developed a breakthrough method of adding a single nitrogen atom to molecules, unlocking new possibilities in drug research and development. Now ...

Heterocycles, molecular rings found in many pharmaceuticals, have a reputation for stubbornly resisting modification. That is, in a heterocycle, heteroatoms of one type aren’t easily swapped for ...

One small atom can make a big difference in a molecule’s pharmacological properties. Especially if that atom is a nitrogen. Chemists at the University of Oklahoma have now unveiled a new strategy for ...

As a graduate student at the University of California, Berkeley, Mark Levin started sketching out ideas for how to do something no chemist had ever managed before: swapping one of the carbon atoms in ...

(Nanowerk News) In pioneering drug development, the new technology that enables the easy and rapid editing of key atoms responsible for drug efficacy has been regarded as a fundamental and "dream" ...

Skeletal editing is a modern approach to chemical synthesis. By making precise alterations at the atomic level, researchers are able to directly convert existing drug scaffolds into new, biologically ...