Researchers show that loss of the SPRTN enzyme lets DNA–protein crosslinks accumulate, leak DNA into the cytoplasm, activate ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in diameter. By comparison, this corresponds to a 40-kilometer thread packed ...

Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...

Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal ...

In an era where the U.S. healthcare system spends $4.5T annually yet faces systemic failures, with life expectancy plummeting to a three-decade low and chronic disease rates at an all-time high, the ...

Kian Sadeghi, Nucleus Founder & CEO, and Alexis Ohanian, Reddit Co-founder and Seven Seven Six founder, join 'Closing Bell Overtime' to talk Nucleus' DNA testing and utilizing AI in gene editing. Got ...

An international research team has provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after ...

The investigations of KIT researchers have shown that biomolecular condensates enable fast yet reliable activation of the right genes. “Biomolecular condensates are tiny drops that form in specific ...