When scientists first came across p53 in 1979, it was an intriguing but not Earth-shattering discovery. Six groups independently discovered a cellular protein with a molecular weight of roughly 53 ...
p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage. Its ...
Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically experience unusually low rates of cancer. The research found these remarkable ...
In the 1970s, scientists knew that some viruses and chemicals caused cancer, but they didn’t know how. Arnold Levine, a biologist currently at the Institute for Advanced Study researched DNA viruses ...
Researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with chronic liver disease. By generating a mouse ...
In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells to ...
A new study has, for the first time, settled the debate about how a mutated protein present in half of all human cancers drives tumor growth. The discovery will not only facilitate a rethink of the ...
Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney Kimmel ...
A new hypothesis article was published in Oncotarget (Volume 17) on January 3, 2026, titled “Hypothesis: HPV E6 and COVID spike proteins cooperate in targeting tumor suppression by p53.” ...
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