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从Phidippus audax毒液中分离、合成并药理表征一种结构简单的肽类物质 ...
盐沼蜘蛛(Phidippus audax)毒液中短肽Paudax1的分离、合成及电生理特性研究。通过HPLC分离、固相合成和电生理学方法发现,Paudax1为22氨基酸的单二硫键肽,具有昆虫麻痹活性。两种N端异构体Phi-Ala和Phi-Trp中,Phi-Trp对大鼠背根神经节神经元外向电流的抑制效果更 ...
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