A team of researchers at the University of Cologne’s Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that ...

Selective ASO-based JAK2 inhibitor for the treatment of hematological malignancies with JAK2 V617F mutation burden. Use of causal modeling to uncover cell-cell communication dynamics in the tumor ...

In the fight against disease, programmed cell death – also known as apoptosis – is a key protective function of the body. It breaks down cells that are damaged or have undergone dangerous changes.

New research shows that physical pressure from brain tumors or injuries triggers a "self-destruction" program in neurons, leading to irreversible brain damage.

Researchers have discovered how to block cells dying, in a finding that could lead to new treatments for neurodegenerative conditions like Parkinson's and Alzheimer's. The team at WEHI, including ...

RIPK1 inhibition reduced inflammation and keratinocyte cell death in lichen planus and CLE models. Could this be a new ...

Programmed cell death (PCD) stands at the forefront of innovation in experimental pharmacology and drug discovery, providing fundamental insights into ...

New basic science insights into programmed cell death could offer relief for inflammatory bowel disease. Many people with IBD, an umbrella term that includes ulcerative colitis and Crohn's disease, ...

Investigators have reported that three doses of the anti-programmed cell death protein 1 immunotherapy pembrolizumab – given prior to surgery – left no detectable cancer at time of operation ...