To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Nonoptimal-codon usage is one aspect of the many hidden codes enabled by the redundancy of the genetic code that constrains the ability of protein-coding sequences to evolve 26.

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Codon adaption–based control of protein levels has two major advantages over existing techniques. First, it allows preservation of 3′ and 5′ untranslated regions and thus endogenous genetic ...

Genetic Code Supports Targeted Insertion of Two Amino Acids by One Codon Science, 323 (5911), 259-261 DOI: 10.1126/science.1164748 Subscribe to the feed Related Topics ...

Codon bias, the probability that one codon of three adjacent nucleotides will code for one amino acid over another, was previously thought to be the cause for protein expression variance, but it ...

DNA has often been called “the book of life,” but this popular phrase makes some biologists squirm a bit. True, DNA bears our genes, which spell out the instructions our cells use to make ...

The codon 129 variant confers some protection against prion disease only when it is present on one of the two copies of the gene that encodes the protein. But transgenic mice with the codon-127 ...

Overview of mRNA coding region design for two well-established objectives, stability and codon optimality, using SARS-CoV-2 Spike protein as an example.