R-loop是一种由RNA：DNA杂合链和单链DNA组成的特殊核酸结构，在原核和真核生物的基因组中分布广泛且普遍存在。R-loop在很多关键的生物学过程中发挥重要功能，包括染色质修饰、转录调控、DNA损伤修复以及基因组稳定性等，但其如何被精确调控的机制尚不清楚。

这篇研究揭示了甲基磷酸帽酶(MePCE)在DNA损伤修复中的新机制。研究发现7SK RNA甲基转移酶MePCE被动态招募到双链断裂(DSB)位点，以与BRCA1协同的方式促进R-loop解离和同源重组(HR)修复。这项工作不仅阐明了染色质相关MePCE与DNA修复因子的相互作用网络，还为BRCA1缺陷型 ...

本研究揭示了DNA结合蛋白AND-1通过直接结合R-loop结构并增强RNase H1的核酸内切酶活性，在调控R-loop动态平衡中的关键作用。研究人员发现AND-1缺失会导致乳腺组织R-loop积累，并通过破坏雌激素受体阳性（ER+）乳腺癌细胞中ESR1基因增强子区域的R-loop调控来降低ESR1 ...

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called ...

Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...