空间 rna 组织在多种细胞过程和疾病中起关键作用，但因扰动特定亚细胞区域内源性 rna 的技术有限，其功能影响尚未充分探索。研究人员开发 crispr-to 系统，利用 rna 引导的核酸酶失活 dcas13，实现活细胞内源性 rna 定位的可编程控制，为相关研究提供新平台。

Core的合成环状RNA将主要用于基因表达和非编码功能，类似于病毒、质粒或信使RNA——这些元素是开发基因和细胞疗法的关键。 麻省布里格姆GCTI总指挥Nathan Yozwiak博士表示：基因和细胞治疗研究正在为未来的各种重症患者的新治疗铺平道路，我们相信环状RNA的应用会帮助我们走得更远。

研究团队利用云计算与ai技术发现超16万种新rna病毒，是已知种类的近30倍，深化了对rna病毒多样性和演化历史的认知，并带来病毒学新发现。

Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we ...

These edits modify RNA, the molecule used to translate information from the genetic blueprint stored in DNA, while leaving the DNA unaltered. Scientists don’t yet know for sure why octopuses ...

RNA plays a key role in protein synthesis. My team and I were curious about whether RNA might actively participate in fixing double-strand breaks as a first line of defense.

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Orbital Therapeutics has raised an eye-popping $270 million for its collection of RNA tools and pursuit of next-gen medicines, while also managing to bring two new execs into its circle. ...

Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. We conducted a ...

Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepa ...

A team of Swedish-Norwegian scientists have recovered RNA from a 130-year-old Tasmanian tiger specimen, marking the first time this molecule has ever been sequenced in an extinct animal.