Several mechanisms have evolved that regulate the biogenesis of specific classes of small RNA using variations on the same core processing machinery. Most animals encode a single Dicer protein ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

Alternative pathways of RNA processing are regulated in response to signaling cues often coordinating expression of gene networks in response to physiological change including in development and ...

Most of these proteins are RNA-binding proteins that are involved in distinct steps of RNA processing, maturation, transport and the regulation of RNA stability and translation. Interestingly ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Our laboratory carried out research in two areas. In one, we studied the structure and mechanism of activity of the catalytic RNA moiety of the RNA processing enzyme ribo-nuclease P (Rnase P). In the ...

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies protein synthesis and impacts RNA processing in Alzheimer's ...

Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

Trypanosomes are parasites that cause sleeping sickness, Chagas disease, and various animal diseases. Diagnosis and treatment remain complex and no effective vaccine has been developed. A better ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

This study not only discovered a novel 3′ UTR-derived sRNA but also expanded the understanding of RNase III-mediated RNA processing. It highlights the critical role of ManNAc in bacterial ...

These factors use the cap-binding complex as a platform to lead the RNA to its next processing step or to a new location in the cell. Unlike its human counterpart, which has two sub-units ...