RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

Traditional PCR systems require users to set a specified number of cycles according to the assay and the input amount. As a result, input material must be quantified, and samples of varying inputs ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Increasing paternal age has been linked to elevated health risks for the next generation, including higher risks of obesity ...

According to research from a team at the University of Utah Health and the University of Nevada, Reno School of Medicine, ...

Learn more about the DNA and RNA that sperm carry and how they may suddenly change during midlife.

Researchers found that sperm RNA profiles shift with paternal age in both mice and humans. Using PANDORA-seq, they identified ...

By Dr. Priyom Bose, Ph.D. A newly revealed “aging cliff” in sperm RNA marks a conserved molecular transition from youth to later life, offering fresh insight into how a father’s age may influence the ...