STAT

Randomized controlled trials are the ‘gold standard’ of research — but a difficult fit for trans care

In order to provide gender-affirming care, clinicians must sometimes jump through unusual hoops. In Australia, for example, the government won’t subsidize testosterone treatment for a trans man ...
Medscape

‘Major Gap’ in Many Randomized Controlled Trials of Major Depressive Disorder

AMSTERDAM — At least one third of patients with major depressive disorder (MDD) would not qualify for inclusion in many randomized controlled trials (RCTs) that help guide the use of antidepressants, ...
ascopubs.org

Surgery Versus Ablation for Hepatocellular Carcinoma: A Randomized Controlled Trial (SURF-RCT Trial) and a Nonrandomized Prospective Observational Trial (SURF-Cohort Trial)

Impact of Lean Body Mass–Based Oxaliplatin Dose Calculation on Neurotoxicity in Adjuvant Treatment of Stage III Colon Cancer: Results of the Phase II Randomized LEANOX Trial The trials were conducted ...
TCTMD

SAVR Bests TAVI for 5-Year Survival in Combined RCT, Observational Data

COPENHAGEN, Denmark—Five-year survival following surgical aortic valve replacement (SAVR) for aortic stenosis is superior to that of TAVI, according to an analysis combining data from more than three ...
City Journal

Clear the Way for Clinical Trials

Randomized controlled trials are the key to medical innovation, but they have become substantially more expensive in recent decades. A series of regulatory changes could bring RCT costs down and ...
Morningstar

Landmark STORM-PE Randomized Controlled Trial Finds Computer Assisted Vacuum Thrombectomy (CAVT) with Anticoagulation Superior to Traditional Anticoagulation Treatment for ...

ALAMEDA, Calif., Oct. 27, 2025 /PRNewswire/ -- Penumbra, Inc. (NYSE: PEN) announced the results of the landmark STORM-PE randomized controlled trial (RCT), which found that the use of mechanical ...
EurekAlert!

RCT-DUPLICATE findings demonstrate capability of real-world evidence studies to reach conclusions similar to randomized clinical trials

NEW YORK, April 25, 2023 ‒ Aetion ®, the global leader in real-world evidence (RWE) technology and analytics, is pleased to announce the culmination of the RCT-DUPLICATE demonstration project, with ...