How, though, would a DNA-degrading enzyme distinguish between the two? Arber hypothesized that bacterial cells might express two types of enzymes: a restriction enzyme that recognizes and cuts up ...

3 In 1970, Hamilton Smith and Kent Wilcox from Johns Hopkins University discovered “endonuclease R” (later named HindII), a restriction enzyme isolated from Hemophilus influenza. 1 A year later, ...

Moreover, the specificity of a restriction enzyme is dependent on environmental conditions. For this reason, scientists looked for ways of improving the accuracy of restriction enzymes and of ...

The study, published in the journal Cell Death & Disease, reveals important progress in unraveling how the enzyme, angiotensin-converting ... such as small for gestational age births, fetal growth ...

HindIII, for example, is an H. influenzae restriction enzyme that recognizes the sequence 5'AAGCTT-3' (upper strand)/3'TTCGAA-5' (lower strand) and cleaves between the two A's on both strands.