Helicases and nucleic acid translocases are motor proteins that have essential roles in nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin remodelling.

These enzymes play essential roles in a variety of processes ... 1,2 as chemo-mechanical agents that control DNA structure. Since then helicases have been the subject of extensive biochemical ...

Paradoxically, a tumor suppressor role of VGLL3 was also reported in ... be recruited to DSBs in a PARylation- and ...

R-loops play a vital role in regulating gene expression, DNA replication ... METTL3, and the helicase DDX21 strongly colocalize. (A helicase is an enzyme that separates the two strands of a ...

The research uncovers the vital role of a protein called ... IIα (TOP2A), in untangling the DNA threads. Second, it works with a protein called BLM helicase to convert tangled threads into ...

Building on these findings, the team further investigated the role of PICH in ... (TOP2A), in untangling the DNA threads. Second, it works with a protein called BLM helicase to convert tangled ...