Proceedings of the Pennsylvania Academy of Science, Vol. 41 (1967), pp. 10-15 (6 pages) Using a fresh unfixed muscle preparation and phase contrast microscopy, the entire sequence of morphological ...

Striated muscle contraction requires intricate interactions of microstructures. The classic textbook assumption that myosin filaments are compressed at the meshed Z-disc during striated muscle fibre ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, using electron cryo-tomography (cryo-ET). The international ...

BOULDER, Colo.--(BUSINESS WIRE)--Edgewise Therapeutics, Inc., (Nasdaq: EWTX), a clinical-stage biopharmaceutical company focused on developing orally bioavailable, targeted, small molecule therapies ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...