在湿式实验室验证中，DrugCLIP实现了15%的去甲肾上腺素转运蛋白命中率，并且在与靶蛋白的复合物中确定了两种已鉴定抑制剂的结构。对于甲状腺激素受体相互作用因子12，一种缺乏全结构和小分子结合物的靶标，DrugCLIP仅使用AlphaFold2预测结构就达到了17.5%的命中率。最后，研究人员发布了GenomeScreenDB，这是一个开放的数据库，提供了针对5亿种化合物筛选的约10，000种人 ...

Science in the United States has never been stronger by most measures. Over the past five years, the nation has won more scientific Nobel prizes than the rest of the world combined — in line with its ...

Research by philosopher of science and Honorary Research Associate at Bangor University, Byron Hyde, looked at the role of transparency in fostering public trust in science. Hyde argues that, to find ...

From “experimental archaeology” to the mysterious appeal of exploration, the wide-ranging subjects detailed in these titles captivated Smithsonian magazine’s science contributors this year Joe Spring, ...

— #25: Ancient hominid species famous for their 'upright' posture — 11 across ...

“By amplifying human intelligence, AI may cause a new Renaissance, perhaps a new phase of the Enlightenment,” Yann LeCun, one of the godfathers of modern artificial intelligence (AI), suggested ...

We explain the administration’s cuts to research. By Alan Burdick I’m an editor and occasional reporter of health and science news. Late yesterday, Sethuraman Panchanathan, whom President Trump hired ...

Mr. Edsall contributes a weekly column from Washington, D.C., on politics, demographics and inequality. A substantial number of Republican voters are losing faith in science. In April 2020, 14 percent ...