The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.

Figure 1: Natural variation and evolution of stalk positioning correlates with SpmX localization. Figure 2: SpmX specifies the location of stalk synthesis in Asticcacaulis. Figure 3: Evolution of the ...

We propose a sequential approach for constructing multiple-objective locally optimal designs for nonlinear models. The technique used here is a general one and we demonstrate the added benefits of ...

The paper develops methods for the comparison of randomized rules of the biased coin type for the sequential allocation of treatments in a clinical trial. One important characteristic is the loss, ...