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Nature:李贵登团队发现癌症免疫治疗新靶点——KLHL6,有望增强T细胞 ...
撰文丨王聪编辑丨王多鱼排版丨水成文在相当一部分患者中,基于 T 细胞的癌症免疫疗法(例如 CAR-T 细胞疗法、TCR-T 细胞疗法)的持久性仍然有限。肿瘤微环境(TME)中 T 细胞功能障碍是疗效的主要障碍,其部分原因在于 T 细胞耗竭、线粒体功能障碍以及各种免疫抑制因子。尽管在转录组学和表观基因组学方面已对 T ...
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