Previous studies had only observed exhaustion under chronic antigen stimulation, according to the authors. Additionally, they found that impaired mitochondrial complex III function reduced CD8 + ...

A new predictive framework reprograms T cells to sustain immune memory while preserving their ability to fight cancer and infections.

Scientists have discovered key genetic factors that determine whether a T cell acts as a powerful disease fighter or enters ...

Scientists uncover a new “recipe” that shows how exhausted T cells can be reprogrammed to regain their ability to attack tumors.

For San Diego researchers and the wider immunotherapy community, the atlas functions as a practical roadmap. It does not ...

CD8⁺ T cells are the frontline soldiers of the body against cancer, but their prolonged exposure to tumor antigens often leads to an exhausted state ...

A multi-institutional study led by researchers at UNC Lineberger Comprehensive Cancer Center, the Salk Institute for Biological Studies, and UC San Diego has uncovered new genetic rules that determine ...

Contrary to public concerns, receiving frequent COVID-19 booster vaccinations will not weaken the immune system, providing reassurance to vulnerable groups facing new variants. Study: No evidence of ...

This image shows killer T cells surrounding and attacking a cancer cell. A new atlas developed by researchers at UC San Diego could make it possible to design custom T cells for immunotherapy to ...

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...