生命科学Life science2025年10月2日，中国科学院分子细胞科学卓越创新中心许琛琦课题组、中国科学院深圳先进技术研究院合成生物学研究所施小山课题组与上海科技大学王皞鹏课题组合作，在Cell Press细胞出版社旗下期刊Molecular ...

在肿瘤免疫治疗领域，免疫检查点抑制剂（ICI）尤其是PD-1/PD-L1阻断剂，已在多种癌症类型中展现出显著的临床效益。然而，仍有大量患者对ICI治疗无响应或产生耐药性，其背后的机制尚未完全阐明。近年来研究表明，肿瘤微环境（TME）中的代谢应激是导致 ...

T-cell engagers, especially BiTEs, show promise in treating solid tumors by targeting tumor-associated antigens and redirecting T-cell activity. Tarlatamab, targeting DLL3 in SCLC, demonstrated ...

封面图：六孔长笛象征着 TCR 复合物的关键信号亚基 CD3ζ，其含有六个酪氨酸磷酸化位点。正如覆盖或揭开不同的孔会产生不同的声音一样，不同酪氨酸的磷酸化和去磷酸化会产生不同的信号输出。该研究描述了 CD3ζ ...

Preclinical data support Abalos’ first-in-class approach of safely harnessing the immunostimulatory and anti-tumoral properties of ...

A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects. Protein complexes that adorn the surface of T cells ...

Avantor, Inc. (NYSE: AVTR), a leading global provider of mission-critical products and services to customers in the life sciences and advanced technologies industries, today announced a strategic ...

AVTR collaborates with BlueWhale Bio to speed CAR-T manufacturing using CDNP tech, aiming to scale production and expand patient access.

Liberate Bio, Inc., a biotechnology company developing genetic medicines that deliver RNA therapies directly to immune cells, today announced new preclinical data presented at the American Society of ...