在肿瘤免疫治疗领域，免疫检查点抑制剂（ICI）尤其是PD-1/PD-L1阻断剂，已在多种癌症类型中展现出显著的临床效益。然而，仍有大量患者对ICI治疗无响应或产生耐药性，其背后的机制尚未完全阐明。近年来研究表明，肿瘤微环境（TME）中的代谢应激是导致 ...

撰文丨王聪编辑丨王多鱼排版丨水成文T 细胞恶性肿瘤是一组异质性疾病，复发率和死亡率都很高，其总体预后通常不佳（尤其是与 B 细胞恶性肿瘤相比）。尽管目前诸如化疗之类的策略对某些疾病亚型有益，但对于复发或难治性疾病患者，其疗效仍然有限。因此，开发针对 ...

Three scientists have been awarded the 2025 Nobel Prize in physiology or medicine for discovering how the body stops its own ...

Nobel laureate Shimon Sakaguchi reflects on the role of regulatory T cells in peripheral immune tolerance and how the cells ...

Scientists have found a way to transform hard-to-treat tumors into targets for the immune system. Using two protein ...

A small but key UK study has found that "cellular immunity" to the pandemic SARS-CoV-2 virus is present after six months in people who had mild or asymptomatic COVID-19 - suggesting they might have ...

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi receive the prize for understanding how the immune system is kept in ...

Researchers at the University of Missouri School of Medicine have recently found that a certain protein may have a large ...

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