撰文丨王聪编辑丨王多鱼排版丨水成文在相当一部分患者中，基于 T 细胞的癌症免疫疗法（例如 CAR-T 细胞疗法、TCR-T 细胞疗法）的持久性仍然有限。肿瘤微环境（TME）中 T 细胞功能障碍是疗效的主要障碍，其部分原因在于 T 细胞耗竭、线粒体功能障碍以及各种免疫抑制因子。尽管在转录组学和表观基因组学方面已对 T ...

方向二：赋能现有尖端疗法 KLHL6的潜力不止于单独用药。它极有可能成为 下一代细胞免疫疗法（如CAR-T、TCR-T）的“超级增强组件” ...

The immune system relies on complex interactions between cells to orchestrate effective responses against pathogens and tumours. Among these, T cells play a pivotal role through their ability to ...

Low-dose aspirin may limit cancer metastasis by inhibiting platelet activation and enhancing T-cell immunity, supporting biomarker guided use while balancing bleeding risk overall.

The fight against cancer is undergoing a paradigm shift with the emergence of innovative strategies in Cancer Immunity & Immunotherapy. These approaches harness the body's own immune system to ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Cancer immunotherapy is a type of cancer treatment that harnesses the immune system to fight cancer cells. The treatment ...

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in ...

Bacterial vaginosis (BV) is an awfully common—and awful—condition that impacts 1/4 to 1/3 of women worldwide in their lifetime. BV is triggered when the vaginal microbiome, which is normally dominated ...

Cancer scientists have been working against the clock for decades to outsmart a disease that comes back more powerfully after treatment. Traditional treatments like chemotherapy, radiation, and even ...

A new study reveals how bacteria in the gut can help determine whether the amino acid asparagine from the diet will feed ...