Despite advances in the treatment of patients with the most severe forms of asthma, progress remains to ... that it is possible to specifically target Th2 lymphocytes, the main culprits of type ...

Dr Samhita says that this subset of asthma patients exhibits heightened immune activity, driven by specific cells, including: T helper type 2 (Th2) cells – These play a pivotal role in asthma ...

Silent rhinovirus (RV) infection is prevalent in nasal tissues and is associated with distinct immune responses in those with and without chronic rhinosinusitis with nasal polyps (CRSwNP). These were ...

which are early source of IL-4 to assist DCs for Th2 polarization. Controlling the activity of basophils can be therapeutically beneficial in early stage asthma. This work was supported by NIH ...

Allergic asthma is the most common form of asthma ... Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen, Nature Immunology (2024).

Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma. The house dust mite allergen Der p ...