Timing of troughs Troughs should be obtained at steady state: approximately prior to the fifth dose IIB Optimal trough concentrations Should be >10 mg/l at a minimum to avoid development of ...

Expert Rev Anti Infect Ther. 2011;9(6):657-667. The impact of combination therapy upon the need for aggressive vancomycin dosing was not discussed in the guidelines but a recent review failed to find ...