实验中发现,在深度为 32 时,HC 的 Amax 值飙升至 6500 倍,并伴随着剧烈的波动,而 mHC 值则稳定保持在 1.0。在深度为 48 时,这种模式再次出现:HC 猛增至 3500 倍,而 mHC 值保持不变。
A functional immune system must be able to effectively recognize and fight pathogens while staying tolerant to the body’s own components. This is achieved by central and peripheral tolerance ...
Figure 1: Developmental progression during MHC I positive selection. Our results indicate that MHC I positive selection proceeds in two sequential phases that are defined by dynamic changes in CD8 ...
MHC-II限制性新抗原疫苗通过促进T细胞浸润和IFN-γ分泌重塑冷肿瘤免疫抑制微环境,联合TIGIT阻断剂可协同增强抗肿瘤效果并延缓T细胞耗竭。 背景与意义 由于缺乏足够的T细胞浸润,冷肿瘤对免疫检查点抑制剂的反应不佳。CD4 + T细胞在抗肿瘤免疫中的重要性日益 ...
Our core provides customized MHC/peptide tetramers for identification of antigen-specific T lymphocytes by flow cytometry. Tetramers and/or their derivatives are provided for research purposes only.
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