CRISPR gene editing has been used to more than double the lifespan of mice engineered to have the premature ageing disease progeria, also greatly improving their health. The results far surpassed ...

Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a rare genetic disease that causes extreme premature ...

The gene-editing method known as base editing might be a way to address the underlying cause of Hutchinson-Gilford progeria syndrome (HGPS or progeria), a rare genetic disease that leads to ...

Jan H. J. Hoeijmakers is in the Molecular Genetics Department, Erasmus MC, 3015 GD Rotterdam, the Netherlands, and also at the Princess Máxima Center for Pediatric Oncology, Oncode Institute and at ...

In children with progeria, a mutant protein accumulates in blood vessel cells, hampering their ability to grow and multiply or killing them outright. In mice that produce this same toxic protein, the ...

In the spring of 2005, families affected by progeria welcomed the news from two studies that uncovered new information about this rare, devastating condition that causes premature aging in children.