为解决药物致心律失常风险评估中传统交叉点-并集检验(IUT)方法样本量需求大的问题，研究人员开发了基于t检验的系统性样本量计算方法。该方法通过浓度-QTc(C-QTc)分析显著降低样本量需求，经实际分析验证与模拟研究结果一致，为临床心脏安全性评价提供了 ...

Tyrosine kinase inhibitors (TKIs) are associated with prolongation of the QTc interval on the electrocardiogram (ECG). The QTc-interval prolongation increases the risk of life-threatening arrhythmias.

To examine gender differences in rate-corrected QT interval (QTc), an index of ventricular depolarization/repolarization, in young, trained men and women with lower ...