Scientists reveal splicing-based mechanism driving therapy resistance in pediatric acute myeloid leukemia

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have ...

Alternative RNA splicing tied to schizophrenia-like behaviors in animal models

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...
Science Daily

What role does alternative splicing play in neurodegenerative disease?

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -- single-stranded RNAs involved in protein synthesis -- and proteins from the same stretch of DNA, ...
Science Daily

Model demonstrates how RNA splicing defects contribute to Alzheimer's disease

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...
GEN

RNA Splicing Visualized, Easing the Design of Small-Molecule Modulators

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...
Fred Hutch

Circling back to RNA sequencing data to map recursive splice sites

The human genome is just over 6 feet 8 inches long, which is 2 inches taller than the average NBA basketball player and in total, a lot of nucleotides! But what if the amount of sequence diversity ...
GEN

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...