撰文丨王聪编辑丨王多鱼排版丨水成文在相当一部分患者中，基于 T 细胞的癌症免疫疗法（例如 CAR-T 细胞疗法、TCR-T 细胞疗法）的持久性仍然有限。肿瘤微环境（TME）中 T 细胞功能障碍是疗效的主要障碍，其部分原因在于 T 细胞耗竭、线粒体功能障碍以及各种免疫抑制因子。尽管在转录组学和表观基因组学方面已对 T ...

The immune system relies on complex interactions between cells to orchestrate effective responses against pathogens and tumours. Among these, T cells play a pivotal role through their ability to ...

方向二：赋能现有尖端疗法 KLHL6的潜力不止于单独用药。它极有可能成为 下一代细胞免疫疗法（如CAR-T、TCR-T）的“超级增强组件” ...

Low-dose aspirin may limit cancer metastasis by inhibiting platelet activation and enhancing T-cell immunity, supporting biomarker guided use while balancing bleeding risk overall.

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

The fight against cancer is undergoing a paradigm shift with the emergence of innovative strategies in Cancer Immunity & Immunotherapy. These approaches harness the body's own immune system to ...

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in ...

Cancer immunotherapy is a type of cancer treatment that harnesses the immune system to fight cancer cells. The treatment ...

Bacterial vaginosis (BV) is an awfully common—and awful—condition that impacts 1/4 to 1/3 of women worldwide in their lifetime. BV is triggered when the vaginal microbiome, which is normally dominated ...

Cancer scientists have been working against the clock for decades to outsmart a disease that comes back more powerfully after treatment. Traditional treatments like chemotherapy, radiation, and even ...

A new study reveals how bacteria in the gut can help determine whether the amino acid asparagine from the diet will feed ...