本研究针对纤维性结构不良(FD)这一由Gαs激活突变引发的骨骼疾病，通过构建条件性转基因小鼠模型，首次证实蛋白激酶A(PKA)是FD发生发展的核心效应因子。研究人员发现PKA激活可诱导骨骼干细胞(SSCs)异常分化并促进破骨细胞生成，而通过基因工程抑制剂肽(PKI)或 ...
Figure 1: In vitro and in vivo detection of a PKA-dependent phospho-Smo isoform. Figure 2: The PKA subunit C1 is necessary for Smo phosphorylation and stabilization. Figure 3: The Cos2/Fu complex ...
The 8-Bromo-cAMP sodium salt PKA activator, a synthetic analog of cAMP, is one of the most potent tools of investigating and playing with this pathway, which has become an essential part of ...
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