University of Alabama at Birmingham researchers, led by Jianyi “Jay” Zhang, M.D., Ph.D., and Lei Ye, M.D., Ph.D., generated the human leukocyte antigen-knockout and cyclin D2-overexpressing hiPSCs, ...

Long before human bone marrow takes over the task of producing blood, discrete waves of blood cell production occur in the developing embryo. Miriana Dardano, a postdoctoral researcher in Zweigerdt’s ...

Your heart will not just give you fear and uncertainty after a heart attack; it can leave scar tissue that stiffens your heart and limits your strength. Many people learn to live with that loss, but ...

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that ...

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves ...

Injecting infarcted pig hearts with specially bioengineered cells significantly decreased the infarct area and improved heart function, showing possible clinical relevance “It is widely acknowledged ...

A mouse study of heart failure with preserved ejection fraction (HFpEF) found male-female differences at the cellular level. The findings could have implications for how HFpEF is treated in women ...