Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveal their inner structures. It occurs during an essential step of imaging ...

The most amazing thing about cryo-EM is that it allows us to examine processes that used to be the subject of theory and speculation as we had no means to observe the motion and components ...

Cryo-EM also holds the potential for studying membrane lipids and proteins in their near-native state, resolving long-standing questions about the architecture and nature of lipid microdomains.

But, Kihara said, cryo-EM’s low-resolution image data means building structure models of proteins, nucleic acids and drug molecules is not trivial. “Current data processing, including structure model ...

Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold. Proceedings of the National Academy of Sciences , 2023; 120 (37) DOI: 10. ...

Okinawa Institute of Science and Technology (OIST) Graduate University researchers have uncovered the atomic structure of the “APOBEC3G-Vif complex” using cryo-electron microscopy. Their ...

Cryo-electron microscopy (cryo-EM) is a powerful technique used to determine the three-dimensional structure of biological macromolecules, such as proteins and viruses, at near-atomic resolution.

This protein forms amyloid structures, which researchers at Universitat Autònoma de Barcelona (Spain) have characterized using cryo-EM, advancing our understanding of the implications of amyloid ...

Cryo-electron microscopy (cryo-EM) has advanced rapidly in the past few years, positioning itself as an invaluable tool for the pharmaceutical industry. Nobel Laureate Richard Henderson predicted ...

Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveal their inner structures. It occurs during an essential step of imaging ...