引言 我们长期信奉着一条近乎真理的中心法则：DNA转录为mRNA，mRNA翻译为蛋白质。在这种线性的逻辑下，mRNA往往被视为蛋白质的忠实代理人。过去十年，单细胞测序技术（scRNA-seq）的爆发，让我们习惯于通过统计mRNA的数量来推断细胞的功能状态，仿佛掌握了剧本（转录本），就等于看到了演出（蛋白质功能）。 然而，剧本真的等于演出吗？

How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

南方科技大学朱健康院士团队在The Innovation 期刊在线发表的最新研究进展：“mRNA-engineered CRISPR-Cas epigenetic editors enable durable and efficient gene ...

In today’s rapidly evolving scientific landscape, eliminating barriers to progress is more critical than ever. Precision medicine and targeted therapies hold great promise but are dependent on the ...

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine—which designs nanotechnology-based ...

N of 1 therapy uniquely developed, on demand, for infant with life-threatening rare metabolic disorder in six months Results published in The New England Journal of Medicine and showcased at American ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...