Abstract. Objective: Hippo signaling pathway is known to regulate organ development. In Hippo signaling pathway, YAP or TAZ works as a transcriptional co-activator and forms a transcriptional complex ...

AbstractPurpose:. Antibody–drug conjugates (ADC) are a promising approach for the management of patients with non–small cell lung cancer (NSCLC). However, only a small subset of patients derive ...

Abstract. Introduction: Increasing evidence suggest that epigenetic regulators play a critical role in cancer cell heterogeneity and in maintaining tumor sub-populations with enhanced tumor-initiating ...

Abstract. Interleukin-2 (IL-2) offers therapeutic potential for cancer treatment, however, its clinical application is limited due to systemic adverse effects, such as vascular leakage syndrome (VLS).

Abstract. Background: ASC63 is an oral small molecule programmed cell death-ligand 1 (PD-L1) inhibitor. After oral dosing, ASC63 is rapidly absorbed and converted to its pharmacologically active ...

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy characterized by uncontrolled proliferation of hematopoietic stem and progenitor cells and failure to differentiate into mature ...

Although considerable efforts have been dedicated to identifying predictive signatures for immune checkpoint inhibitor (ICI) treatment response, current biomarkers suffer from poor generalizability ...

AbstractPurpose:. Anlotinib has achieved good results in clinical trials of a variety of cancers. However, the effects of anlotinib on the tumor microenvironment (TME) and systemic immunity have not ...

These studies demonstrate that certain KRAS G12C inhibitors effectively target all RAS G12C mutations and that sotorasib specifically is a potent NRAS G12C inhibitor capable of driving clinical ...

Estrogen receptor (ER) alpha signaling is a known driver of ER-positive (ER +)/human epidermal growth factor receptor 2 negative (HER2 −) breast cancer. Combining endocrine therapy (ET) such as ...

Our laboratory previously examined the effects of walnuts on mouse models of intestinal disease (6 – 9). Using the colon carcinogen azoxymethane, we tested the effects of walnuts added to Total ...

AbstractBackground:. Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphoblastic leukemia (ALL).Methods:. We conducted a ...