Until a little over two decades ago, hypoplastic left heart syndrome was considered an inoperable and fatal condition, with most deaths occurring in early infancy, and almost all of those affected ...

Transition from neonatal to paediatric intensive care of very preterm-born children: a cohort study of children born between 2013 and 2018 in England and Wales (9 December, 2024) ...

Neonatal thrombocytopenia is a common clinical problem. Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet ...

Background Neonatal research evaluates many different outcomes using multiple measures. This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to ...

Objective To determine if preterm birth is associated with adaptation of the hypothalamic–pituitary–adrenal (HPA) axis and whether HPA axis programming relates to the degree of prematurity (defined as ...

The management of low blood flow states in premature neonates is fraught with many challenges. We remain over-reliant on regimented stepwise protocols that use mean blood pressure as a threshold for ...

Cerebral injury and retinopathy as risk factors for blindness in extremely preterm infants (27 September, 2024) ...

Healthcare decisions should be based on all relevant evidence.1 Usually, this is provided by randomised controlled trials (RCTs) comparing two or more interventions for a condition affecting a target ...

The changing management of haemolytic disease of the newborn is reviewed In the space of most paediatricians working lifetime, the spectrum of haemolytic disease of the newborn (HDN) has changed ...

Patient safety incidents (PSIs) occur relatively frequently in healthcare. Incident-reporting systems are designed to systematically collect information relating to PSIs in order to identify and ...

Objective To evaluate if postnatal treatment with betamethasone in extremely preterm infants was associated with neurodevelopmental impairment (NDI) at 6.5 years of age. Design Prospective cohort ...

Objective To evaluate the accuracy of neonatal MRI and general movements assessment (GMA) in predicting neurodevelopmental outcomes in infants with hypoxic-ischaemic encephalopathy (HIE). Design ...