Introduction and Objectives Approximately 1 in every 4100 people worldwide are born with oesophageal atresia ± tracheo-oesophageal fistula (OA/TOF). Whilst surgical correction is, in most cases, ...

Methods TRIVERSYTI is an ongoing phase III multi-centre (China, South Korea and Taiwan), randomized, parallel group trial comparing a 24-week treatment with (BDP/FF/GB) 100/6/12.5 µg pMDI, 2 puffs bid ...

Method Adults with a first-recorded code for breathlessness (index date) and subsequent coded diagnosis between 2007 and 2017 were included from a UK primary care database (CPRD-GOLD). Cox regression ...

Background and objectives IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder originally described in association with autoimmune pancreatitis (AIP), usually but not always in ...

Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...

Background Exposure to tobacco content in films is a cause of smoking uptake in young people. In an earlier study, we reported that tobacco content occurred in 70% of UK box office films popular ...

Background Smoking has been considered an important risk factor for idiopathic pulmonary fibrosis (IPF) incidence. However, there are no population-based large-scale studies demonstrating the effects ...

Introduction Better patient selection for non-invasive ventilation (NIV), and time to NIV initiation, are national improvement objectives.1Treatment escalation planning (TEP) was also identified ...

Introduction Observational studies suggested lung function is inversely associated with cardiovascular disease (CVD) although these studies could be confounded. We conducted a two sample Mendelian ...

Method People referred for CXR from primary care to a single acute district general hospital in London attended sessions that were prerandomised to either immediate radiographer (IR) reporting or ...

Introduction Despite improvements in pulmonary function, physical activity (PA) levels remain significantly lower than the general population, even at 1 year following lung transplantation (LTx).

Disease burden Any prioritisation of the respiratory research agenda requires accurate data on underlying disease burden. The British Lung Foundation (now Asthma+Lung UK) has in the past supported ...