SORL1 RESEARCH MODELS ADDED. SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Dennis Selkoe Co-Director, Brigham and Women's Hospital's Ann Romney Center for Neurologic Diseases; Posted: 21 Mar 2019 This morning’s news that an interim analysis by Biogen of their Phase 3 ...

04 May 2023. Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an ...

28 Sep 2022. Eisai and Biogen yesterday announced positive topline results from the Phase 3 Clarity trial of their anti-amyloid antibody lecanemab.The drug slowed decline on the primary endpoint, ...

John Morris Washington University School of Medicine; Posted: 20 Nov 2020 In 37 years of caring for persons with Alzheimer’s disease dementia, and in conducting clinical and translational research to ...

Overview. Name: Nasal Insulin Synonyms: Detemir, Levemir, Humulin, Novolin, glulisine Therapy Type: Small Molecule , Other Target Type: Amyloid-Related , Other Condition(s): Alzheimer's Disease, Mild ...

Takaomi Saido RIKEN Center for Brain Science; Posted: 21 Nov 2022 There seems to be some misunderstanding about our App (Saito et al., 2014; Watamura et al., 2022), MAPT (Hashimoto et al., 2019), and ...

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

We have developed this special section of the Alzforum website to provide a resource for all who share an intense interest in familial early-onset AD (eFAD). We have created this series of articles ...

20 Jan 2022. After months of uncertainty, the hammer fell for Biogen: In a draft decision released January 11, the Centers for Medicare and Medicaid Services proposed to cover the anti-amyloid ...

25 Jan 2024. Not so long ago, a blood test for Alzheimer’s disease seemed a pipe dream. Now, after years of study, the field is awash with sensitive assays that signal the proteopathic culprits Aβ and ...

This database is a repository of normal genetic variability, designed to be a tool for researchers who study neurodegenerative disease. It contains whole-exome sequencing results from nearly 500 ...