Loss-of-function (LOF) technologies are widely used across many model organisms and many fields. Although all LOF approaches have the shared goal of perturbing gene function, there are complex ...

A new study identifies molecular factors that promote small vessel disease—and an active drug that can restore impaired ...

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across ...

Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional ...

Sleep deprivation effects harm brain health, impairing memory, attention, and emotion. Chronic loss risks neurodegeneration ...

AB SCIENCE ANNOUNCES NEW PUBLICATION ON MEDRXIV HIGHLIGHTING CLINICAL BENEFIT WITH MASITINIB IN AMYOTROPHIC LATERAL SCLEROSIS PATIENTS PRIOR ANY COMPLETE LOSS OF FUNCTION Significant improvement in ...