The human genome contains approximately 1,600 types of transcription factors responsible for regulating gene activity across ...

Large-scale human genetics studies have shown that many risk variants for common and complex diseases sit in the non-coding ...

Researchers at Duke University used CRISPR technologies to discover previously unannotated stretches of DNA in the ‘dark genome’ that are responsible for controlling how cells sense and respond to the ...

University of Wisconsin researchers Sushmita Roy and Erika Da-Inn Lee have developed a new computational tool that maps changes in the genome, ultimately helping researchers see DNA’s 3D organization ...

DNA's double helix has long stood as the symbol of life’s code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...

April 14, 2025 – Genome Research (https://genome.org) publishes a second special issue highlighting advances in long-read sequencing applications in biology and medicine. In this second Special Issue, ...

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in ...