Introduction: High-quality randomised controlled trials (RCTs) provide the most reliable evidence on the comparative efficacy of new medicines. However, non-randomised studies (NRS) are increasingly ...

BMJ Evidence-Based Medicine (BMJ EBM) publishes original evidence-based research, insights and opinions on what matters for health care. We focus on the tools, methods, and concepts that are basic and ...

Clinical Decision-Making; Delivery of Health Care; Evidence-Based Practice; Patient Care; Care happens in interaction between the patient and the clinician, in conversation where the patient and ...

Journal clubs, typically involving a group of health professionals or trainees who discuss recent study findings, have long ...

A systematic review identifies, appraises and synthesises all the empirical evidence from studies that meet prespecified eligibility criteria to answer a specific research question. As part of the ...

Objectives Generative artificial intelligence (GAI) tools can enhance the quality and efficiency of medical research, but their improper use may result in plagiarism, academic fraud and unreliable ...

New government legislation is necessary to ensure full transparency of industry payments in the UK’s healthcare. A first step should involve challenging the industry-driven discourse that allows ...

Transparency in clinical trials: an established norm across sectors. Access to data for drugs and vaccines has historically been fairly limited to journal article publications and hard-to-access and ...

Objective To investigate the decisional impact of an age-based chart of kidney function decline to support general practitioners (GPs) to appropriately interpret estimated glomerular filtration rate ...

Background The comparative effectiveness of non-pharmacological treatments of depression remains unclear. Methods We conducted an overview of systematic reviews to identify randomised controlled ...

Objectives Despite rising rates of multimorbidity, existing risk assessment tools are mostly limited to a single outcome of interest. This study tests the feasibility of producing multiple disease ...

> Why then, can one desire too much of a good thing? > > William Shakespeare, As You Like It (1600) Rosalind’s question, as she is about to marry Orlando, is purely rhetorical—she thinks that one ...