Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on ...

This valuable study presents an analysis of the gene regulatory networks that contribute to tumour heterogeneity and tumor plasticity in Ewing sarcoma, with key implications for other fusion-driven ...

An evolutionary perspective on immune priming across plants and invertebrates highlights the roles of microbiomes and epigenetic regulation in shaping innate immune memory with promising applications ...

Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel ...

Songbird HVC sequences arise from a balance of ionic currents and structured inhibition, providing a mechanistic framework for understanding cortical sequence generation.

This useful study demonstrates that microsaccade direction primarily indexes shifts rather than the maintenance of covert spatial attention, offering a focused interpretation that may help reconcile ...

This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse by reanalyzing nearly 400 Ribo-seq datasets using a standardized pipeline; ...

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.

We highlight recent developments in eLife’s equity, diversity and inclusion framework and what steps we plan to take next ...

Hydration modulates aromatic interactions, explaining why Tyr is a stronger sticker than Phe in aqueous environments like protein condensates but not in the cores of folded proteins.

A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.

Step selection functions are a useful tool for analysing fine-scale human movements to understand environmental interactions in the context of infectious disease epidemiology.