Background Systemic lupus erythematosus (SLE) is an inflammatory disease with complex genetic underpinnings. SLE association at 2p22.3 is one of the most consistently replicated SLE signals. We ...

Objectives Nearly 20% of pregnancies in patients with SLE result in an adverse pregnancy outcome (APO). We previously developed an APO prediction model using logistic regression and data from ...

Objective The aim of this study was to analyse the 2020 burden of Systemic Lupus Erythematosus (SLE) in Europe, from the patients’ perspective.Methods In May 2020, Lupus Europe, the European umbrella ...

Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. Visual analogue scales (VAS) allow rapid, continuous scaling of disease ...

Objectives To achieve consensus on domains of active disease for inclusion in a novel outcome measure for SLE randomised controlled trials (RCTs), the Treatment Response Measure for SLE ...

Objective To assess the economic burden of patients with SLE by disease severity in the USA 1 year before and after diagnosis.Methods Patients aged ≥18 years with a first SLE diagnosis (index date) ...

Objective To achieve consensus on a definition of remission in SLE (DORIS).Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been ...

Objective This study sought to elucidate the molecular impacts of belimumab (BEL) treatment on T-cell immune profiling in SLE.Methods We used mass cytometry with 25 marker panels for T-cell immune ...

Objective CC-97540 (BMS-986353) is an investigational CD19 CAR T-cell therapy utilizing the lisocabtagene maraleucel CD19-directed CAR T construct with a 41BB co-stimulatory domain and an epidermal ...

Introduction Neuromyelitis optica spectrum disorder (NMOSD) is a rare immune-mediated disease affecting the spinal cord and optic nerves. While NMOSD has been widely studied, limited data exist on the ...

Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, ...

Objective It is still a matter of debate whether low-dose acetylsalicylic acid (LDASA) should be prescribed to all patients with SLE during pregnancy. This study aimed at investigating the impact of ...