我们正在继续努力进行体细胞核移植，以获得免疫相容的胚胎干细胞，用于未来患者的再生医学应用。 由于人类卵母细胞的可用性有限，我们从卵巢肿瘤患者那里获得了人类卵巢皮质碎片，并设计了体外激活方案以促进休眠卵泡的生长，然后移植到免疫缺陷小鼠体内以获得成熟的卵母细胞。 我们 ...

该项目增强了干细胞的可及性、可扩展性和协作性。它提供了特征化的 hPSC 系、CRISPR 编辑和自动化平台上的分化，从而加速了生物学、疾病研究和再生医学的进展。… 继续阅读 干细胞建模的模块化自动化方法可提高通量、再现性和可及性 ...

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 在成人CM中，Ca (2+)诱导的Ca (2+)通过兰尼碱受体 (RyR)从肌浆网 (SR)释放是兴奋-收缩耦合的关键。 因此，hESC 衍生的 CM 需要具有适当的 Ca (2+) 处理特性，才能与受体心脏成功进行功能整合。 在这里 ...

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 我们最近报道，Ca (2+) 处理对于 hESC 衍生的 CM (hESC-CM) 的兴奋-收缩耦合至关重要，具有功能性但不成熟。 胞质Ca (2+)瞬时幅度较小、动力学较慢和肌浆网 (SR)Ca (2+)含量减少等不成熟特性可归因于特定Ca ...

250+ Clinical Trials: Hosted at Alpha Clinics for CIRM funded and other research. 2000+ Patients Enrolled: Pioneers who participated in a clinical trial at an Alpha Clinic. 40+ Diseases & Conditions: ...

The California Cell and Gene Therapy Manufacturing Network was established by CIRM to expand the manufacturing capabilities necessary to bring stem cell and gene therapies from foundational research ...

CIRM, was created by the voters of California in 2004 when they overwhelmingly passed Proposition 71, which authorized $3 billion in funding for stem cell research in California. The agency funds stem ...

Foundation – Discovery Stage Research Projects Qiong Annabel Wang Utilizing Age-Specific Adipocyte Progenitor Cells for Cell Therapy in Older Patients $1,508,997 Clinical Trial Stage Projects Prof.

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