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Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan ...

Bell palsy is an idiopathic weakness or paralysis of the face of peripheral nerve origin, with acute onset. It affects 20–30 persons per 100 000 annually, and 1 in 60 individuals will be affected over ...

Background: The relation between emergency department opioid prescribing and subsequent harm is complex and poorly studied. We sought to quantify adverse outcomes, incremental risk, and rates of ...

What are the key steps of the exploration phase? The development of successful machine-learned solutions requires a deep understanding of the problem at hand, relevant outcomes, the data that are ...

Recommendation The Canadian Task Force on Preventive Health Care recommends against instrument-based depression screening using a questionnaire with cut-off score to distinguish “screen positive” and ...

Background: Cancer surveillance data are essential to help understand where gaps exist and progress is being made in cancer control. We sought to summarize the expected impact of cancer in Canada in ...

Most antihistamines are safe during pregnancy and breastfeeding Systematic reviews of observational studies show no association with adverse fetal or maternal outcomes with antihistamine use during ...

Smoking marijuana can increase clearance of some drugs Smoked marijuana increases the clearance of theophylline 40%. 1 Similar findings would be expected for other drugs metabolized by CYP1A2, such as ...

Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline ...

Background: Although diacetylmorphine has been proven to be more effective than methadone maintenance treatment for opioid dependence, its direct costs are higher. We compared the cost-effectiveness ...

Kerri L. Schellenberg, Gudrun Caspar-Bell, Colin Ellis, Wendy Johnston, Alexandra King, Malcolm King, Lawrence Korngut, Brendan Kushneriuk, Andrea J. Lavoie, Reid ...