In this study, we generated new in-vivo treatment models of Brca1- and Bard1-mutant breast cancer that recapitulate the striking response to PARPi, acquired resistance, and recurrence that is observed ...

DDX5 is the most abundant RNA helicase and is aberrantly expressed in most malignant tumors, where it participates in transcriptional regulation, differentiation, metastasis, and regulation of various ...

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

Astrocytes are generated from radial glial cells (RGCs) in the ventricular zone during brain development (Kriegstein and Alvarez-Buylla, 2009; Lin et al, 2021).In the dorsal neocortex, RGCs express ...

Perturbations in the proteostasis machinery play an important role in modulating aging-associated pathways (Balch et al, 2008; Hipp et al, 2019; Jayaraj et al, 2020; Klaips et al, 2018; Labbadia and ...

We demonstrate that TP53 deficiency in AML cells confers resistance to CAR T-cell therapy by inducing CAR T-cell dysfunction. We propose a model in which difficult-to-kill TP53-mutant AML cells ...

The bacterial homolog DgoT (from E. coli) transports negatively charged galactonate in symport with more than one proton and, thus, differs from mammalian SLC17s in both its main substrate and ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent fission yeast cells. Deletion of ...

The plant root system plays a fundamental role as a point of contact with the plant surroundings and allows adaptation to multiple stresses. Contrary to primary roots, lateral root (LR) development is ...

ITM2B/BRI2 mutations cause Alzheimer’s Disease (AD)-related dementias. We observe heightened ITM2B/BRI2 expression in microglia, a pivotal cell type in AD due to risk-increasing variants in the ...

Authors can choose to publish the referee reports, editorial correspondence and decision letters alongside their paper – and more than 95% of our authors do. Our editors will respect the exclusion of ...