Central retinal artery occlusion can result in permanent vision loss. Effective treatment is lacking. We conducted a phase 3, double-blind, double-dummy, randomized, controlled trial involving ...

Explore this issue of The New England Journal of Medicine (Vol. 0 No. 0).

A 63-year-old man presented with a 3-month history of chest tightness, palpitations, and abdominal pain. Laboratory studies ...

A number of therapies that have been shown to be effective in patients with chronic heart failure, including beta-blockers, mineralocorticoid receptor antagonists, and renin–angiotensin system ...

A 50-year-old man presented with a 1-year history of progressive headaches. On examination, there was neck stiffness and dysmetria in both arms. An MRI of the head showed Eiffel-by-night sign.

Rare disease in an adolescent who lived more than 12,000 years ago, along with her burial embrace by a first-degree relative, may reflect the importance of care for survival. Ancient DNA analysis l ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a ...

Explore this issue of The New England Journal of Medicine (Vol. 374 No. 4).

Artificial Intelligence has tremendous potential to advance clinical practice and the delivery of patient care.

We randomly assigned patients with type 2 diabetes and chronic kidney disease (defined by an estimated glomerular filtration rate [eGFR] of 50 to 75 ml per minute per 1.73 m 2 of body-surface area and ...

In this phase 3 trial, we randomly assigned patients with resectable, macroscopic stage III melanoma to two cycles of neoadjuvant ipilimumab plus nivolumab followed by surgery or surgery followed by ...

Primary care physicians have been leaving traditional practices for concierge and direct primary care practices, in which patients are offered personalized and more accessible primary care in excha ...